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Nexium and Prilosec product liability and personal injury kidney failure lawsuits are being investigated against AstraZeneca, the drugs manufacturer. These drugs and others in the same class are known as Proton Pump Inhibitors (PPIs). There several hundred claims under investigation alleging chronic kidney disease, acute kidney injury, acute interstitial nephritis, renal failure, and kidney failure after the use of Proton Pump Inhibitors.

Nexium & Prilosec Lawsuits
Nexium & Prilosec medications linked to acute and chronic kidney injury. Many lawsuits are being investigated and under consideration.

According to experts, there are an increased risk of both acute and chronic kidney injury from proton pump inhibitor side effects. Proton Pump Inhibitors, are blockbuster heartburn drugs, which includes Nexium, Prilosec, Protonix, and Prevacid and others.

Proton Pump Inhibitors reduces the acid in the stomach, and are popular drug treatments for gastroesophageal reflux disease (GERD), heartburn, peptic or stomach ulcers and esophageal acid damage.

Proton Pump Inhibitors, A Multi Billion Dollar Industry

Proton Pump Inhibitors are a huge billion dollar pharmaceutical revenue stream in the U.S., with Nexium raking in $6 billion per year in sales. The television and print ads are awash in PPI drug advertising, especially since these drugs are available over the counter.

PPIs and Kidney Damage Link

Nexium, Prilosec and other proton pump inhibitors are linked to an increased risk of acute kidney injury, chronic kidney disease, acute interstitial nephritis and other kidney problems.

In an April 2015 report in the medical journal CMAJ Open, researchers found that PPIs may increase the risk of kidney injury and acute interstitial nephritis, an inflammatory kidney disease that can lead to kidney failure. Once the kidneys fail, patients are doomed to chronic dialysis or waiting for kidney transplantation.

In an February 2016 report in the medical journal JAMA Internal Medicine, researchers found an increased risk of chronic kidney disease with use of proton pump inhibitors. Users of Nexium, Prilosec and other PPI heartburn drugs may face a 50% higher risk of chronic kidney disease when compared to non-users.

According to researchers, PPI may lead to chronic kidney disease through recurrent acute kidney injury. The researchers recommended that doctors provide patients with a detailed risk analysis, suggest alternative types of treatments and avoid indiscriminate use of these potentially dangerous group of medications.

Most recently, in the Journal of the American Society of Nephrology, researchers compared the acid reflux drug kidney risks among users of PPIs and a different group of heartburn drugs, known as histamine H2-receptor antagonists, or H2 blockers.

Researchers found that users of Nexium, Prilosec or other PPIs may be 96% more likely to develop kidney failure and 28% more likely to develop chronic kidney disease.

Over the five year period, 15% of all PPI users developed chronic kidney disease. The researchers also found that the longer the medications are taken, the greater the risk of developing chronic kidney disease.

Injured individuals diagnosed with chronic kidney problems are now considering Nexium and Prilosec lawsuits against the makers of proton pump inhibitors, claiming that the drug makers knew or should have known about the kidney risks, and yet failed to warn patients and doctors.

2014 FDA Warning Label Change

In December 2014, the FDA required a number of warning label changes, adding information for the first time about the risk of acute interstitial nephritis seen among users of proton pump inhibitor.


  1. Gravatar for John Reilly

    I have been taking Nexium 40mg. twice daily for 7 years. It worked great but I now have chronic kidney disease. Please email me some info on future procedures.

  2. Gravatar for BENJAMIN DAILEY

    Have been taking Prevacid for over ten years and my kidneys have been steadily going south - I am now

    consulting with my Internal Medicine Doctor for a change - Ben

  3. Gravatar for Rose

    My husband was taking meds for heartburn for 15 plus years. He ended up with esophageal cancer, main cause of esophageal cancer is acid reflux. All they had to do is a upper GI to find it. I lost him 2 months after finding out. Would like to know why it is not one of the first test done.

  4. Gravatar for Chris Juett

    I have been taking Nexium for a few years

    and last November had my left kidney removed and was told it was cancer.

  5. Gravatar for Audrey F Roberts
    Audrey F Roberts

    I was proscribed prilosec some years ago for acid reflux by my pcp and was diagnosed with chronic kidney disease in 2009 and would like information about the Law suit, before taking this drug I had no major health problems.

  6. Gravatar for Audrey F Roberts
    Audrey F Roberts

    I was proscribed prilosec some years ago for acid reflux by my pcp and was diagnosed with chronic kidney disease in 2009 and would like information about the Law suit, before taking this drug I had no major health problems. I have not submitted this comment before. Thank you

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